Date

April 1995

Document Type

Thesis

Degree Name

M.S.

Department

Dept. of Applied Physics

Institution

Oregon Graduate Institute of Science & Technology

Abstract

A new method of measuring the level of 8-methoxypsoralen in blood serum was developed for the reasons of speed, accuracy, and cost. This new method uses laser induced fluorescence of the psoralen to determine the concentration in serum. The fluorescence is analyzed with an optical multichannel analyzer coupled to an intensified photodiode array detector. Research was first attempted on samples with ethanol as the solvent to confirm that the method would work. Sample concentrations of 8-methoxypsoralen in serum are determined by comparing the fluorescence signal obtained from previously known concentrations. Levels down to 200ng per milliliter of serum can be measured with this technique.

Identifier

doi:10.6083/M48W3B84

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