Date

August 1988

Document Type

Thesis

Degree Name

M.S.

Department

Dept. of Environmental Science and Engineering

Institution

Oregon Graduate Center

Abstract

A technique to measure arsenobetaine and arsenocholine in fish tissue by fast atom bombardment mass spectrometry was developed with particular attention to quantitative analysis. Experiments were performed which demonstrate analysis of the compounds desorbed directly from thin layer silica chromatography matrices, quantitative analysis of arsenobetaine in real fish samples, and accurate mass measurement of arsenobetaine in normal FAB/MS using peaks from the glycerol matrix as mass references. Improvements to the technique to quantitatively measure these important arsenic metabolites are suggested including optimization of the extraction/isolation procedures and use of isotopically labelled internal standards or surrogates for more accurate measurements.

Identifier

doi:10.6083/M4Q81B12

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