Author

Jianji Yang

Date

June 2007

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Medical Informatics and Clinical Epidemiology

Institution

Oregon Health & Science University

Abstract

Tools to automatically summarize gene information from the literature have the potential to help genomics researchers better interpret gene expression data and investigate biological pathways. Even though several useful human-curated databases of information about genes already exist, these have significant limitations. First, their construction requires intensive human labor. Second, curation of genes lags behind the rapid publication rate of new research and discoveries. Finally, most of the curated knowledge is limited to information on single genes. As such, most original and up-to-date knowledge on genes can only be found in the immense amount of unstructured, free text biomedical literature. Genomic researchers frequently encounter the task of finding information on sets of differentially expressed genes from the results of common highthroughput technologies like microarray experiments. However, finding information on a set of genes by manually searching and scanning the literature is a time-consuming and daunting task for scientists. For example, PubMed, the first choice of literature research for biologists, usually returns hundreds of references for a search on a single gene in reverse chronological order. Therefore, a tool to summarize the available textual information on genes could be a valuable tool for scientists. In this study, we adapted automatic summarization technologies to the biomedical domain to build a query-based, task-specific automatic summarizer of information on mouse genes studied in microarray experiments - mouse Gene Information Clustering and Summarization System (GICSS). GICSS first clusters a set of differentially expressed genes by Medical Subject Heading (MeSH), Gene Ontology (GO), and free text features into functionally similar groups;next it presents summaries for each gene as ranked sentences extracted from MEDLINE abstracts, with the ranking emphasizing the relation between genes, similarity to the function cluster it belongs to, and recency. GICSS is available as a web application with links to the PubMed (www.pubmed.gov) website for each extracted sentence. It integrates two related steps, functional gene clustering and gene information gathering, of the microarray data analysis process. The information from the clustering step was used to construct the context for summarization. The evaluation of the system was conducted with scientists who were analyzing their real microarray datasets. The evaluation results showed that GICSS can provide meaningful clusters for real users in the genomic research area. In addition, the results also indicated that presenting sentences in the abstract can provide more important information to the user than just showing the title in the default PubMed format. Both domain-specific and non-domain-specific terminologies contributed in the informative sentences selection. Summarization may serve as a useful tool to help scientists to access information at the time of microarray data analysis. Further research includes setting up the automatic update of MEDLINE records; extending and fine-tuning of the feature parameters for sentence scoring using the available evaluation data; and expanding GICSS to incorporate textual information from other species. Finally, dissemination and integration of GICSS into the current workflow of the microarray analysis process will help to make GICSS a truly useful tool for the targeted users, biomedical genomics researchers.

Identifier

doi:10.6083/M48050KT

School

School of Medicine

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