Date

September 2008

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Science & Engineering

Institution

Oregon Health & Science University

Abstract

In many biological systems, information about the environment is detected by a large array of sensory receptors; it reaches more central regions of the nervous system as parallel streams of spike trains. How this flow of information is processed and which features are most salient to the organism is a central problem in neuroscience. A comprehensive and systematic approach to the analysis of the relationships between stimuli and their neural representations is illustrated. This approach is complementary to the hypothesis driven research paradigm, where the investigator states a hypothesis and then performs experiments in order to validate or invalidate the stated hypothesis. This alternative methodology enlarges the possible relationships between stimuli and their representations beyond one specific hypothesis and aims to evaluate all possible relationships between neural stimuli and their neural representations. For a specific set of data, both the set of stimuli and the set of neural response are characterized either by membership in discrete categories or as a continuous space with a similarity measure. In order to quantify these input-output relationships, existing methods of analysis are adapted or new ones developed where necessary. In the specific data sets analyzed here, timing emerges as a critical parameter for the description of neural stimuli and their representations.

Identifier

doi:10.6083/M4610X8S

Division

Div. of Biomedical Engineering

School

School of Medicine

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.