Date

6-10-2015

Document Type

Thesis

Degree Name

M.P.H.

Department

Dept. of Public Health and Preventive Medicine

Institution

Oregon Health & Science University

Abstract

Background. From 1951 to 1989, the Fernald Feed Materials Production Center released uranium dust into the atmosphere and ground water, resulting in contamination of the surrounding rural area. Residents expressed multiple health concerns, one of which was thyroid health. Little research has examined the effects of uranium exposure and autoimmune thyroid disease (AITD) in the general population. The Fernald Resident Medical Monitoring Program (FMMP) provides a unique opportunity to examine the presence of AITD among a cohort of adults with individually estimated airborne uranium exposure. Purpose. To evaluate the association between uranium exposure and AITD. Demonstration of an association would alert FMMP physicians to be especially aware of thyroid health among participants who live or have lived in the Fernald area leading to early detection and treatment. Methods. ICD-9 codes assigned to disease conditions over the 18-year follow-up on 8,787 adult FMMP participants were used to identify cases of AITD. Cases were frequency matched by year of birth and sex to create a 1:4 case-control ratio. Identified incident cases were categorized into four AITD outcomes, all AITD Cases and three subcategories: a) Hashimoto Thyroiditis (ICD-9: 245.2), b) Graves’ Disease (ICD-9: 242.0), and c) Idiopathic Myxedema (ICD-9: 244.9). Cumulative airborne uranium exposure groups (low0.50 ug/m3) were created by FMMP investigators based on the individual continuous cumulative exposure estimates established through the efforts of the CDC Fernald Dosimetry Reconstruction Project. Multivariate logistic regression was used to examine the odds of exposure type for each of the case outcome categorizations, adjusting for covariates. Results. Cumulative airborne uranium exposure was not found to be associated with any of the AITD categories. Conclusion. We failed to demonstrate an association between cumulative airborne uranium exposure and any of the AITD categories, in the FMMP population. While the community should be made known of the limitations of this study, based on our results, we suggest that AITD is not a top concern for the exposed residential population around Fernald. We believe that standard AITD screening and treatment procedures are sufficient for this population.

Identifier

doi:10.6083/M4FT8JS3

School

School of Medicine

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.