Date

May 2009

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Physiology and Pharmacology

Institution

Oregon Health & Science University

Abstract

The purpose of this dissertation is to study the role of neuronal synchrony and high frequency oscillations in perceptual processing in the auditory cortex of awake behaving rats. In order to do so, I first characterized these oscillations in the primary auditory cortex of rats passively listening to tones. After finding the high frequency oscillations are induced by auditory stimulus in the passively listening rats, I then proceeded to correlate these oscillations with meaningful simple tone patterns. I trained rats in a two-tone discrimination paradigm in which they had to perceive that two successive acoustic events signaled a reward. Moreover, because these two-tones were played in a fast temporal succession, which is commonly seen in a variety of animal vocalizations, the data produced can, in principle, indicate time processing properties of the auditory cortex. The experimental data gathered in this thesis strongly suggest that high frequency oscillations at gamma and high gamma ranges are modulated by auditory perception. I will show in Chapter 1 that tones induce high frequency oscillations. Then, in subsequent chapters (chapters 3 and 5), I will demonstrate that these oscillations are modulated by attention-related processes involved in auditory processing.

Identifier

doi:10.6083/M47D2S46

School

School of Medicine

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.