Date

April 2008

Document Type

Thesis

Degree Name

M.S.

Department

Dept. of Dietetics and Nutrition

Institution

Oregon Health & Science University

Abstract

Background: Quercetin, an abundant flavonoid in the diet, has been shown to have several effects on prostate cancer cell lines, where quercetin can decrease colony formation and increase apoptosis. Quercetin appears to have an impact on numerous markers for prostate cancer. Objectives: 1) The purpose of this study is to evaluate the effects of dietary intake of quercetin as measured by the National Cancer Institute’s Diet History Questionnaire (DHQ) and risk of prostate cancer. 2) A secondary objective is to evaluate the association between dietary intakes of quercetin, and the presence of inflammation in prostate tissue. Setting and Subjects: In this case control study; subjects include all men referred to the Portland VA Medical Center (PVAMC) urology clinic for a prostate biopsy, and Prostate Specific Antigen normal controls(PSA<4 ng/mL) receiving care through PVAMC primary care. Men completed a detailed food frequency questionnaire that also captured lifestyle and tumor characteristics. Methods: Quercetin was added to the DHQ software by this researcher. Dietary intake of quercetin was divided into quartiles and odds of prostate cancer (as compared to clinic controls and to biopsy negative controls separately) were determined using unconditional logistic regression. The association between dietary intake of quercetin and the presence of inflammation was determined using binomial logistic regression. Results: None of the regression analyses reached statistical significance.

Identifier

doi:10.6083/M4J38QH8

School

School of Medicine

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