Author

Rebecca Allen

Date

May 2011

Document Type

Thesis

Degree Name

M.P.H.

Department

Dept. of Public Health and Preventive Medicine

Institution

Oregon Health & Science University

Abstract

Introduction: Cognitive impairment is common in multiple sclerosis (MS). The negative consequences of cognitive impairment on daily activities makes early detection important, but subjective cognitive complaints may be attributed to depression. In this study we sought to add to current understanding of cognitive impairment in MS by examining its relationship to quality of life, depression, self-perception of deficits, and caregiver perception of deficits. We also closely examined the relationship between subjectively reported, caregiver reported, and objectively measured cognitive impairment in MS. Methods: A neuropsychological battery of tests, measures of mental and physical quality of life (the mental [MCS] and physical [PCS] composite scores of the Short Form-36), the Perceived Deficits Questionnaire (PDQ), and the Beck Depression Inventory (BDI) were administered to 119 MS patients participating in a clinical trial. The Multiple Sclerosis Neuropsychological Questionnaire-Informant

Identifier

doi:10.6083/M4F47M3P

School

School of Medicine

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