Date

September 2011

Document Type

Thesis

Degree Name

M.S.

Department

Graduate Programs in Human Nutrition

Institution

Oregon Health & Science University

Abstract

Background: The consumption of fructose has increased substantially in recent decades due to the increased use of added sugars, including sucrose and high-fructose corn syrup in food products. This trend of increasing fructose consumption has mirrored the rising trend in obesity rates in the U.S. Current research suggests that excessive consumption of fructose may increase the risk of obesity, cardiovascular disease, and type 2 diabetes. Objectives: The primary aim of this study was to determine the effects of a high fructose meal on postprandial substrate oxidation in non-obese, healthy males. Fructose does not stimulate insulin release from the pancreas. Lower insulin concentrations lead to lower leptin release from adipose tissue. Because leptin signals the switch from carbohydrate oxidation in the fed state to lipid oxidation postprandially, we hypothesized that a high fructose meal would result in prolonged carbohydrate oxidation and decreased lipid oxidation. The secondary object

Identifier

doi:10.6083/M40Z7184

School

School of Medicine

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