Date

July 2009

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Molecular and Medical Genetics

Institution

Oregon Health & Science University

Abstract

The Wnt signaling pathway is an essential regulator of the intestinal epithelium, during development and throughout adulthood. Inappropriate activation of this pathway leads to over-proliferation of the epithelium and intestinal cancer, whereas inhibition causes a loss of stem cells and collapse of the intestinal epithelium. To date, there are 19 Wnt ligands that have been identified in both mice and humans, several of which are expressed in the intestine. However, not all Wnt ligands serve to activate the canonical pathway that signals through β-catenin, and the functional role of the various ligands in the intestinal epithelium has not been conclusively determined. In the mature intestine, proliferation is confined to the relatively quiescent stem cells and the rapidly cycling transient-amplifying cells within the intestinal crypts. Although the Wnt signal has previously been reported to regulate all proliferating intestinal cells, this has not been definitively demonstrated. A preci

Identifier

doi:10.6083/M47H1GJH

School

School of Medicine

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