Author

Yun Xin Lim

Date

May 2011

Document Type

Thesis

Degree Name

M.S.

Department

Dept. of Cell and Developmental Biology

Institution

Oregon Health & Science University

Abstract

The Occupational Safety and Health Administration has estimated that two million U.S. workers in the health care, embalming, textile, resin, and plastic industries are exposed to formaldehyde. Formaldehyde is one of the most reactive aldehydes found naturally as an endogenous substance in the human body and in environmental sources such as automobile emissions and tobacco smoke. Increased rates of nasopharyngeal cancer and increased relative risk of myeloid leukemia in workers exposed to formaldehyde have prompted the International Agency for Research on Cancer to classify formaldehyde as a human carcinogen. Even though previous reports have shown a correlation between formaldehyde and cancer, the cellular and mutagenic effects of formaldehyde are not well understood. This is the first report demonstrating altered nuclear content and increased mutant frequency as the consequences of formaldehyde exposure. We show that cells presented centrosome and microtubule defects following formald

Identifier

doi:10.6083/M4Z0365C

School

School of Medicine

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