Author

Sidney P. Kuo

Date

April 2011

Document Type

Dissertation

Degree Name

Ph.D.

Institution

Oregon Health & Science University

Abstract

The brainstem cochlear nuclei form the initial stage for sound processing in the brain. Synaptic inhibition has multiple roles in shaping the output of the neuronal circuits that comprise the cochlear nuclei, yet how inhibitory neurons contribute to cochlear nucleus function is incompletely understood. To identify some of the basic mechanisms that define how inhibition contributes to acoustic processing in the cochlear nuclei, the physiology of auditory brainstem inhibitory neurons and synapses was examined using patch-clamp electrophysiological recording techniques in in vitro brainstem slice preparations. Birds have provided an important model system for investigating sound processing. In Chapter 1, inhibitory currents were compared between functionally distinct nuclei in the chick auditory brainstem. The time course of synaptic inhibition was different between nuclei specialized for relaying temporal information, comparing the timing of binaural inputs, or processing sound intensit

Identifier

doi:10.6083/M4NG4NM0

Division

Neuroscience Graduate Program

School

School of Medicine

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