Date

April 2011

Document Type

Dissertation

Degree Name

Ph.D.

Institution

Oregon Health & Science University

Abstract

Illness is associated with a constellation of symptoms including weakness, malaise, anorexia, weight loss, and inability to concentrate. Motivation and arousal are suppressed, and patients report hypersensitivity to pain and a lack of interest in normally enjoyable activities. Remarkably, these features are present in a wide spectrum of diseases, regardless of etiology. Perhaps because these symptoms are so common, they have in the past been underestimated as being an uncomfortable side effect of the illness process. However, this response represents an evolved adaptive strategy with important survival implications. Known collectively as "sickness behavior", this coordinated set of physiologic changes represents a critical element of the host response to disease. By suppressing an animal's motivational drive, metabolically expensive activities are restricted, allowing energy to be diverted into fueling heat generation (fever) and immune system mobilization. When viewed in the context o

Identifier

doi:10.6083/M40R9MC6

Division

Neuroscience Graduate Program

School

School of Medicine

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