Date

June 2011

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Behavioral Neuroscience

Institution

Oregon Health & Science University

Abstract

Although studies have begun to elucidate the neurobiological underpinnings of ethanol-induced conditioned place preference (EtOH-CPP), they have primarily been limited to the acquisition and expression phases, leaving the mechanisms underlying extinction of the behavior unknown. Therefore, these studies were intended to further our understanding of the specific neurochemistry and neurocircuitry involved in extinction of EtOH-CPP. Chapter 2. The first set of experiments examined the effects of the NMDAreceptor partial agonist, D-cycloserine (DCS), on extinction and reconditioning of EtOH-CPP. The results showed that systemic DCS did not alter extinction of both strong or weak EtOH-CPPs. However, DCS (when administered during the extinction phase) prevented subsequent reconditioning of EtOH-CPP. Chapter 3. The extinction-facilitating effects of DCS depend on ERK signaling, therefore, the second set of experiments was intended to assess the involvement of the ERK pathway in extinction of

Identifier

doi:10.6083/M4ZS2TGD

School

School of Medicine

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