Date

June 2010

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Behavioral Neuroscience

Institution

Oregon Health Sciences University

Abstract

Identification of genetic components underlying alcohol dependence is one primary focus of alcohol research. Although a heritable component for the development of alcohol dependence is well established, specific genetic contributions to alcohol use disorders remain difficult to isolate. However, new strategies are being developed to identify discrete genes influencing ethanol behaviors in rodent models. Quantitative trait loci (QTL) mapping in mice has allowed for the identification of specific chromosomal segments harboring gene(s), called quantitative trait genes (QTGs), that influence ethanol withdrawal convulsion severity; and fine-mapping efforts have reduced these chromosomal regions to sizes amenable to discrete gene identification. Our laboratory employed QTL mapping strategies to identify two high-quality QTGs for ethanol withdrawal severity on mouse chromosomes 1 and 4. Mpdz, located on chromosome 4, encodes the multiple PDZ domain (MPDZ) protein, which is present throughout

Identifier

doi:10.6083/M4JM27MQ

School

School of Medicine

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