Date

June 2012

Document Type

Dissertation

Degree Name

Ph.D.

Institution

Oregon Health & Science University

Abstract

The activity of dopamine neurons in the substantia nigra (SN) is potently influenced by the activity of small-conductance calcium-activated potassium channels (SK channels). This is thought to be due solely to the expression of a single SK family member, SK3. We show that SK2 is also expressed in dopamine neurons of the substantia nigra, and unlike SK3 channels that are homogenously distributed, SK2 is selectively targeted to the dendrites, with the highest expression in the distal dendrites. Blockade of SK2 channels selectively decreased the regularity of pacemaker activity without altering the frequency. Unlike some other cell types in which SK2 is trafficked to the dendrites, SK2 channels in DA neurons did not regulate fast, glutamatergic synaptic transmission.

Identifier

doi:10.6083/M4QN64RP

Division

Neuroscience Graduate Program

School

School of Medicine

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