Dept. of Dietetics and Nutrition
Oregon Health & Science University
Introduction. Recent studies have shown that vitamin D metabolites act on the coagulation cascade to reduce clotting and in an exploratory analysis of ASCENT to reduce thrombembolic events (TE). This inexpensive hormone may be a prophylactic candidate in reducing the leading cause of mortality in the U.S. along with its high physical, emotional, and economic burden. We investigate here for the first time the association of serum vitamin D (SVD) status, intake, and predicted vitamin D score for TE in a large cross-sectional dataset. Methods. Binary logistics regression modeling for TE outcome as a function of vitamin D variables was tested using the National Health and Nutrition Examination Survey (NHANES) III dataset. Vitamin D variables included SVD, intake, as well as the predicted vitamin D score, which is a modified score used in this dataset to represent the long-term SVD status for each individual case in this examination. Additionally Wells Score was computed for each case to see if SVD significantly differed between groups using one way ANOVA. Results and Conclusions. The simple age adjusted models for the majority showed decrease odds of TE for increased SVD, intake, and score except in the case of myocardial infarction (MI) as a function of intake. Once confounders were included in the multivariate model the odds of TE was reduced in all cases for upward trending SVD, intake, and score. Deficiency was associated more with poorer TE outcome while the highest quartile is not always associated with the lowest TE. There is a significant SVD difference between Wells Score groups and a clinically significant difference of ~9 ng/mL when comparing low risk to high risk groups. The results are overall consistent with prior studies and demonstrate that vitamin D is inversely associated TE. Since vitamin D is produced through our skin and available through our diets maintaining optimal serum vitamin D status (SVD) may be an effective public health measure in reducing TE in the U.S.
School of Medicine
Lin, Yueh-Han, "Vitamin D and thrombosis" (2007). Scholar Archive. 807.