Date

3-2007

Document Type

Dissertation

Degree Name

Ph.D.

Department

Department of Neuroscience

Institution

Oregon Health & Science University

Abstract

Drosophila contains one SK channel gene that is most similar to mammalian SK1. As with rodent SK1, traditional characterization attempts have proven difficult. When expressed in heterologous systems, dSK does not reach the cell surface. Chimeras containing the N and C termini of rat SK2 the transmembrane regions of dSK are TEA sensitive and apamin insensitive. Northern blots show that there are two transcripts. The transcripts, as determined by quantitative PCR, are developmentally regulated, with the highest levels of expression found in adult head. SK null flies generated by gamma ray deletion have no overt phenotype.

Identifier

doi:10.6083/M4NK3C1Q

School

School of Medicine

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