Date

May 2013

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Cell and Developmental Biology

Institution

Oregon Health & Science University

Abstract

Evidence is clear that ASPP2 is a tumor suppressor that plays a role in protecting against malignant transformation. What is not known, is precisely how the gene products from the TP53BP2 locus are regulated and how this regulation translates into meaningful action within the cell. Given ASPP2’s role as a proapoptotic tumor suppressor and the established complexity at the TP53BP2 locus, I hypothesized that multiple pathways must regulate ASPP2 expression and that ASPP2 function may be impacted by previously unknown protein isoforms. In Chapter 2, I focus on the discovery and characterization of a novel isoform from the TP53BP2 locus and how it might play a role in promoting tumorigenesis. In Chapter 3, I concentrate on my examination of TP53BP2 as a MYC target gene and the extent to which this regulation affects the established role for ASPP2 as a tumor suppressor.

Identifier

doi:10.6083/M46971KG

School

School of Medicine

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