Author

Weike Mo

Date

March 2013

Document Type

Dissertation

Degree Name

Ph.D.

Department

Dept. of Cell and Developmental Biology

Institution

Oregon Health & Science University

Abstract

The zebrafish is a model organism for hearing and balance research. Although lots of zebrafish mutants have been generated, experimental assessment of auditory and vestibular defects in many of these mutants has not been fully established. Our pioneering work has established a new methodology of measuring the vestibuloocular reflex to quantify vestibular defects in 5 day-old zebrafish larvae. Our study has shown robust eye movements with respect to changes in gravity in zebrafish larvae. We have determined herein the basis of sensitivity of the larval eye movements with respect to the vestibular stimulus, developmental stage, and sensory receptors of the inner ear. Our results provide evidence for a functional vestibulo-oculomotor circuit in 72 hours post-fertilization zebrafish larvae that relies upon sensory input from the anterior/utricular otolith organs. An important function of auditory/vestibular hair-cells is to transmit sensory information to downstream neurons. Hair cells us

Identifier

doi:10.6083/M4S180H2

School

School of Medicine

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