Date

November 2012

Document Type

Dissertation

Degree Name

Ph.D.

Institution

Oregon Health & Science University

Abstract

Nearly 2 of every 1,000 children have congenital deafness. To date, more than more 60 genetic loci have been identified that contribute to nonsyndromic forms of inherited deafness. In order to understand how these genes affect hearing and balance, the Nicolson laboratory in collaboration with a large Tübingen Consortium has identified several genes important for the function of the hair cell, the sensory detector of the auditory, vestibular and lateral-line organ systems in mutagenized zebrafish. This thesis characterizes a new player, Rabconnectinα, and its previously unknown contribution to hearing and synaptic vesicle acidification in hair cells. Chapter 1 gives a background of the literature of hearing with regard to operation of the hair cell and the use of a zebrafish as a genetic model of deafness. Chapter 2 follows the experimental set-up of a new testing procedure for discriminating hearing deficits in zebrafish and presents the role of Rabconnectinα in zebrafish hearing. Chap

Identifier

doi:10.6083/M4Q23X8X

Division

Neuroscience Graduate Program

School

School of Medicine

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.