Date

August 2012

Document Type

Dissertation

Degree Name

Ph.D.

Institution

Oregon Health & Science University

Abstract

The brain is exquisitely sensitive to changes in nutrient availability, thus it is selectively vulnerable to the changes in homeostasis which occur in hypoxic, ischemic, or excitotoxic conditions. However, the brain has the ability to make use of several endogenous neuroprotective responses to such conditions. By understanding these innate mechanisms, it is possible to harness the protection conferred by these processes and to elicit them pharmacologically. Stimulating of Toll-like receptors is one means of conferring prophylactic neuroprotection to the brain in anticipation of an ischemic injury, and adenosine augmentation therapy represents an additional means by which endogenous neuroprotective responses can be elicited to reinstate equilibrium following disruption of homeostasis. The underlying mechanisms governing the induction of neuroprotection are becoming increasingly linked to complex genomic reprogramming. This reprogramming is likely occurring via modification of the epige

Identifier

doi:10.6083/M4BP00S4

Division

Neuroscience Graduate Program

School

School of Medicine

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