Oregon Health & Science University
Background: Hunger and satiety are mechanisms that govern energy intake. Ghrelin is a gut hormone that stimulates hunger and food intake in rodents and humans. In order to become active, ghrelin is acylated by an 8--âcarbon fatty acid. The source of this fatty acid is unknown, but may derive from dietary fat. Methods: Following a baseline 2--âweek, isocaloric low--âfat diet (Lo--âFat), 21 subjects were randomized to one of two additional two--âweek periods in which subjects consumed isocaloric high fat diets: which were composed of equal amounts of polysaturated:saturated:monounsaturated oils (Hi--âFat) or high in medium chain triglyceride (MCT). Following completion of the first high--âfat diet feeding assignment, subjects underwent a 6--âweek washout period and were then fed the alternative high--âfat diet. At the end of each feeding period, blood was taken for measurement of ghrelin levels (acyl--â and desacyl--â) and subjects completed visual analog scores to measure hunger and fu
Graduate Programs in Human Nutrition
School of Medicine
Johnson, Christina M., "The effect of dietary medium chain and long chain triglycerides on acyl ghrelin and relationships to hunger and satiety" (2013). Scholar Archive. 935.