Date

July 2013

Document Type

Thesis

Degree Name

M.P.H.

Department

Dept. of Public Health and Preventive Medicine

Institution

Oregon Health & Science University

Abstract

Background: Epidemiologic associations have been observed between cytomegalovirus and chronic diseases of aging, such as functional impairment, cognitive decline, and frailty. This crosssectional study was designed to evaluate demographic and medical history factors independently associated with CMV seropositivity in men aged ≥ 65 from 6 U.S. cities in the ongoing Osteoporotic Fractures in Men (MrOS) cohort study. Methods: Baseline exam questions captured demographic characteristics, including age, race, education, clinic site, SES, BMI, self-rated health status, morbidities and medications, and number of children. CMV serostatus was determined in a random sample of 1586 of the men using serum samples. Prevalence ratios (PR) and 95% confidence intervals (CI) were calculated to determine associations with the variables listed above. Results: Overall, 73.0% of the men in the cohort were CMV seropositive, an indication of chronic infection. CMV seropositivity increased from 68.9% in tho

Identifier

doi:10.6083/M4Z899F7

School

School of Medicine

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