Department of Biomedical Engineering
Oregon Health & Science University
Cardiovascular disease is the leading cause of death in most developed countries and imparts a massive clinical burden. Numerous devices have been developed to treat cardiovascular conditions, and millions of blood-contacting devices are used worldwide every year. However, unacceptably high rates of thrombosis have precluded the clinical use of numerous devices, such as a small diameter vascular graft or an artificial venous valve. Inspired by the function of the endothelium, the natural lining of blood vessels, this work utilized multiple strategies to incorporate biologically-active modifications onto vascular biomaterials to interact with blood cells and proteins in an attempt to reduce material-induced thrombosis. Work in this thesis characterizes the cellular phenotype of a novel progenitor-derived endothelial-like cell, two in vivo assessments of bioprosthetic venous valve endothelialization, the hemocompatibility consequences of crosslinking a decellularized matrix, and a novel modification of decellularized matrix for protein C activation. This dissertation describes novel biomaterials designed for vascular applications for the advancement of cardiovascular medicine.
School of Medicine
Glynn, Jeremy John, "Biologically-active, anti-thrombotic coatings for vascular biomaterials" (2015). Scholar Archive. 3746.
Available for download on Monday, December 24, 2018