September 2010

Document Type


Degree Name



Dept. of Public Health and Preventive Medicine


Oregon Health & Science University


Objectives: (1) Identify variables associated with retention in an opioid treatment program and (2) investigate the association between continued stimulant use and patient retention. Methods: Patients (n = 153) in an opioid treatment program were enrolled in a clinical trial that randomized participants to six months of buprenorphine /naltrexone or methadone and assessed the measures of liver functioning. A secondary analysis of clinical data assessed patient and program influences on study retention. A Markov chain analysis compared methadone and buprenorphine study participants on the probability of positive urine drug screens for stimulant use. Results: Superior retention time was found in patients on methadone, who began treatment halfway through the study, attended group meetings weekly, had longer periods of time without drug use in the last year, and who were not intravenous users. Buprenorphine was not found to be more effective at decreasing stimulant use than methadone. Co




School of Medicine



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.