June 2011

Document Type


Degree Name



Oregon Health & Science University


Obesity is one of the most prevalent and challenging clinical conditions in society today. It is estimated that 61% of people living in the United States are overweight or clinically obese (1, 2). Obesity is also associated with diseases known to have high inflammatory responses, such as dyslipidemia, and stroke. Elevated circulating omega-3 fatty acid concentrations are associated with decreased markers of inflammation. Previous studies found that increasing omega-3 fatty acid intake in obese subjects during weight loss reduced markers of inflammation and increased insulin sensitivity (3-5). It is possible that weight loss itself alters plasma fatty acid concentrations. Melanocortin 4 receptors (MC4R), located at the end of proopiomelanocortin neurons (POMC), play a role in decreasing food intake and increasing energy expenditure. This study investigated the effect of weight loss induced by a MC4R agonist on plasma fatty acid concentrations in monkeys.




Graduate Programs in Human Nutrition


School of Medicine



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