August 2010

Document Type


Degree Name



Dept. of Cell and Developmental Biology


Oregon Health & Science University


Primitive erythropoiesis is the process that gives rise to the first red blood cells in the vertebrate embryo. It is regulated by signals dependent on GATA transcription factors that originate both within hematopoietic cells as well as in the surrounding microenvironment. In our model system, Xenopus laevis, GATA factors have distinct functions that are required to support primitive erythropoiesis in cells that are fated to form blood, as well as in cells that comprise their surrounding environment. In the first study, we have examined the cellautonomous role of the GATA-transcriptional co-factor, Friend of GATA (FOG) during primitive erythropoiesis. Although FOG is known to be required for primitive erythropoiesis in the mouse, its role in Xenopus and the general mechanism(s) by which it functions during erythropoiesis are unclear. In the studies presented herein, we have established a requirement for FOG during Xenopus primitive erythropoiesis and demonstrated that depletion of endog




School of Medicine



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