Dept. of Cell and Developmental Biology
Oregon Health & Science University
Primitive erythropoiesis is the process that gives rise to the first red blood cells in the vertebrate embryo. It is regulated by signals dependent on GATA transcription factors that originate both within hematopoietic cells as well as in the surrounding microenvironment. In our model system, Xenopus laevis, GATA factors have distinct functions that are required to support primitive erythropoiesis in cells that are fated to form blood, as well as in cells that comprise their surrounding environment. In the first study, we have examined the cellautonomous role of the GATA-transcriptional co-factor, Friend of GATA (FOG) during primitive erythropoiesis. Although FOG is known to be required for primitive erythropoiesis in the mouse, its role in Xenopus and the general mechanism(s) by which it functions during erythropoiesis are unclear. In the studies presented herein, we have established a requirement for FOG during Xenopus primitive erythropoiesis and demonstrated that depletion of endog
School of Medicine
Mimoto, Mizuho Stacy, "Regulatiuon of primitive erytropoiesis in Xenopus laevis" (2010). Scholar Archive. 649.