June 2010

Document Type


Degree Name



Dept. of Behavioral Neuroscience


Oregon Health Sciences University


Identification of genetic components underlying alcohol dependence is one primary focus of alcohol research. Although a heritable component for the development of alcohol dependence is well established, specific genetic contributions to alcohol use disorders remain difficult to isolate. However, new strategies are being developed to identify discrete genes influencing ethanol behaviors in rodent models. Quantitative trait loci (QTL) mapping in mice has allowed for the identification of specific chromosomal segments harboring gene(s), called quantitative trait genes (QTGs), that influence ethanol withdrawal convulsion severity; and fine-mapping efforts have reduced these chromosomal regions to sizes amenable to discrete gene identification. Our laboratory employed QTL mapping strategies to identify two high-quality QTGs for ethanol withdrawal severity on mouse chromosomes 1 and 4. Mpdz, located on chromosome 4, encodes the multiple PDZ domain (MPDZ) protein, which is present throughout




School of Medicine



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