Dept. of Cell and Developmental Biology
Oregon Health & Science University
Evidence is clear that ASPP2 is a tumor suppressor that plays a role in protecting against malignant transformation. What is not known, is precisely how the gene products from the TP53BP2 locus are regulated and how this regulation translates into meaningful action within the cell. Given ASPP2âs role as a proapoptotic tumor suppressor and the established complexity at the TP53BP2 locus, I hypothesized that multiple pathways must regulate ASPP2 expression and that ASPP2 function may be impacted by previously unknown protein isoforms. In Chapter 2, I focus on the discovery and characterization of a novel isoform from the TP53BP2 locus and how it might play a role in promoting tumorigenesis. In Chapter 3, I concentrate on my examination of TP53BP2 as a MYC target gene and the extent to which this regulation affects the established role for ASPP2 as a tumor suppressor.
School of Medicine
Van Hook, Kathryn Dianne, "New insights into the complex regulation and function of ASPP2 tumor suppressor : the discovery of the [delta]N-ASPP2 isoform" (2013). Scholar Archive. 873.