February 2013

Document Type


Degree Name



Dept. of Public Health and Preventive Medicine


Oregon Health & Science University


Background: Cognitive deficits are an early feature of Alzheimer’s disease (AD) and vascular dementia (VD). Brain white matter hyperintensities (WMH), identified with MRI, are thought to represent cerebrovascular pathology and are a risk factor for cognitive decline. Six genes in the 17q25 region were recently identified as being associated with WMH burden. I aimed to test if these genes are associated with cognitive dysfunction in elderly men. Methods: This study was conducted in Osteoporotic Fractures in Men Study (MrOS), a cohort of community-dwelling me age 65 and older. This was a cross-section study comparing 26 SNPs in six genes, TRIM65, TRIM47, FBF1, MRPL38, ACOX1 and WBP2, with outcomes of two cognitive tests, Trails Making Test Part B (Trails B) and the Modified Mini Mental State Examination (3MS). Results: Mean Trails B and 3MS scores were determined to be 129.5±56.3 seconds and 94.1±5.0 points respectively. SNPs in ACOX1, FBF1, and MRPL38 were associated with Trails B and




School of Medicine



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