May 2013

Document Type


Degree Name



Dept. of Public Health and Preventive Medicine


Oregon Health & Science University


Introduction: The incidence of Duchenne muscular dystrophy (DMD) is 1/3500 male births. This disease is progressive; the life expectancy is 25-30 years of age. Children affected by this disease have higher fracture incidence than children in the general population. The factors that influence development of fractures in children with DMD have not been clearly defined. Health-related quality of life is lower in children with DMD than the general pediatric population. Few risk factors for decreased quality of life have been identified, and the potential effect of fractures on quality of life has not been explored. Methods: Subjects were recruited from patients with DMD attending Shriners Hospital for Children in Portland, Oregon. Demographic and medical history was gathered from chart review. A thirty-minute survey was conducted with parents using PedsQL and PedsQL Neuromuscular Module to assess health-related quality of life. Data were analyzed using multivariable linear regression with




School of Medicine



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