Oregon Health & Science University
The brain is exquisitely sensitive to changes in nutrient availability, thus it is selectively vulnerable to the changes in homeostasis which occur in hypoxic, ischemic, or excitotoxic conditions. However, the brain has the ability to make use of several endogenous neuroprotective responses to such conditions. By understanding these innate mechanisms, it is possible to harness the protection conferred by these processes and to elicit them pharmacologically. Stimulating of Toll-like receptors is one means of conferring prophylactic neuroprotection to the brain in anticipation of an ischemic injury, and adenosine augmentation therapy represents an additional means by which endogenous neuroprotective responses can be elicited to reinstate equilibrium following disruption of homeostasis. The underlying mechanisms governing the induction of neuroprotection are becoming increasingly linked to complex genomic reprogramming. This reprogramming is likely occurring via modification of the epige
Neuroscience Graduate Program
School of Medicine
Williams-Karnesky, Rebecca Lynn, "Epigenic changes induced by adenosine agumentation therapy prevent epileptogenesis" (2012). Scholar Archive. 926.