August 2012

Document Type


Degree Name



Oregon Health & Science University


The brain is exquisitely sensitive to changes in nutrient availability, thus it is selectively vulnerable to the changes in homeostasis which occur in hypoxic, ischemic, or excitotoxic conditions. However, the brain has the ability to make use of several endogenous neuroprotective responses to such conditions. By understanding these innate mechanisms, it is possible to harness the protection conferred by these processes and to elicit them pharmacologically. Stimulating of Toll-like receptors is one means of conferring prophylactic neuroprotection to the brain in anticipation of an ischemic injury, and adenosine augmentation therapy represents an additional means by which endogenous neuroprotective responses can be elicited to reinstate equilibrium following disruption of homeostasis. The underlying mechanisms governing the induction of neuroprotection are becoming increasingly linked to complex genomic reprogramming. This reprogramming is likely occurring via modification of the epige




Neuroscience Graduate Program


School of Medicine



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.