June 2013

Document Type


Degree Name



Dept. of Public Health and Preventive Medicine


Oregon Health & Science University


Fall Risk in Relation to Bioavailable Vitamin D: The Osteoporotic Fractures in Men (MrOS) Study Authors: J Cai Gillis, Lynn Marshall, Jodi Lapidus, Iva Miljkovic, Amy H Warriner, Jeffrey R Curtis, Tien Dam, James M Shikany, Peggy M Cawthon, Rene Chun, Martin Hewison, Michael Nevitt, Jane A Cauley, Eric Orwoll, Carrie M Nielson Purpose: Bioavailable 25-hydroxyvitamin D (bio25(OH)D) is that fraction of total 25(OH)D not bound to vitamin D binding protein (DBP). However, little is known about effects of bio25(OH)D on health outcomes. Vitamin D’s potential effects on neurological and muscular outcomes might manifest in a higher fall risk among those with lower levels of bio25(OH)D. In this study, we evaluated associations of bio25(OH)D and total 25(OH)D with risk of falls in elderly men. Methods and Results: The MrOS study enrolled 5,994 ambulatory men ≥65 years old from March 2000 to April 2002 at 6 sites in the US. Total 25(OH)D assays were performed in serum obtained at enrollment




School of Medicine



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