June 2013

Document Type


Degree Name



Oregon Health & Science University


Background: Hunger and satiety are mechanisms that govern energy intake. Ghrelin is a gut hormone that stimulates hunger and food intake in rodents and humans. In order to become active, ghrelin is acylated by an 8--‐carbon fatty acid. The source of this fatty acid is unknown, but may derive from dietary fat. Methods: Following a baseline 2--‐week, isocaloric low--‐fat diet (Lo--‐Fat), 21 subjects were randomized to one of two additional two--‐week periods in which subjects consumed isocaloric high fat diets: which were composed of equal amounts of polysaturated:saturated:monounsaturated oils (Hi--‐Fat) or high in medium chain triglyceride (MCT). Following completion of the first high--‐fat diet feeding assignment, subjects underwent a 6--‐week washout period and were then fed the alternative high--‐fat diet. At the end of each feeding period, blood was taken for measurement of ghrelin levels (acyl--‐ and desacyl--‐) and subjects completed visual analog scores to measure hunger and fu




Graduate Programs in Human Nutrition


School of Medicine



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