July 2013

Document Type


Degree Name



Dept. of Public Health and Preventive Medicine


Oregon Health & Science University


Background: Epidemiologic associations have been observed between cytomegalovirus and chronic diseases of aging, such as functional impairment, cognitive decline, and frailty. This crosssectional study was designed to evaluate demographic and medical history factors independently associated with CMV seropositivity in men aged ≥ 65 from 6 U.S. cities in the ongoing Osteoporotic Fractures in Men (MrOS) cohort study. Methods: Baseline exam questions captured demographic characteristics, including age, race, education, clinic site, SES, BMI, self-rated health status, morbidities and medications, and number of children. CMV serostatus was determined in a random sample of 1586 of the men using serum samples. Prevalence ratios (PR) and 95% confidence intervals (CI) were calculated to determine associations with the variables listed above. Results: Overall, 73.0% of the men in the cohort were CMV seropositive, an indication of chronic infection. CMV seropositivity increased from 68.9% in tho




School of Medicine



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.